Proton pump inhibitors are not antacids!
نویسنده
چکیده
Proton pump inhibitors (PPIs) are among the most commonly prescribed drugs in clinical practice. Since the introduction of these potent acid-suppressing agents in the late 80s, they were listed in the Guinness Book of World Records as the most prescribed in human history. Yet, to be effective in inhibiting the proton pump enzyme (H+/K+ ATPase) in the parietal cells, these drugs should be taken 1 hour before meals.
منابع مشابه
Use of proton pump inhibitors during pregnancy and breastfeeding.
QUESTION A 36-year-old pregnant patient has symptoms of peptic disease. Treatment with diet and lifestyle modifications and also antacids has given her little relief. If she were not pregnant, I would prescribe a proton pump inhibitor (PPI) for her. She is now 4 weeks pregnant, and I need to determine whether PPIs are safe during pregnancy. ANSWER Data currently available suggest that omepraz...
متن کاملPotential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis
Corticosteroids are standard treatment for patients with multiple sclerosis experiencing acute relapse. Because dyspeptic pain is a common side effect of this intervention, patients can be given a histamine receptor-2 antagonist, proton pump inhibitor or antacid to prevent or ameliorate this disturbance. Additionally, patients with multiple sclerosis may be taking these medications independent ...
متن کاملProton pump inhibitor-refractory gastroesophageal reflux disease: challenges and solutions
A significant percentage of patients with gastroesophageal reflux disease (GERD) will not respond to proton pump inhibitor (PPI) therapy. The causes of PPI-refractory GERD are numerous and diverse, and include adherence, persistent acid, functional disorders, nonacid reflux, and PPI bioavailability. The evaluation should start with a symptom assessment and may progress to imaging, endoscopy, an...
متن کاملPrimary Care Practitioners’ Views on the Use of Proton Pump Inhibitors Associated with Alginate-Antacids for Better Gastroesophageal Reflux Disease Symptom Control: Results of a National Survey in Spain
Background: Gastroesophageal reflux disease (GERD) is a prevalent disease in Western countries. Despite effective treatment modalities, in some patients total symptom control is not achieved in clinical practice. A cross-sectional study was designed to assess primary care practitioners’ views on the effectiveness of proton pump inhibitors (PPI) as monotherapy in the control of the most common s...
متن کاملScience review: The use of proton pump inhibitors for gastric acid suppression in critical illness
Prophylaxis is routinely provided for critically ill patients admitted to intensive care units (ICUs) who are at high risk for stress-related mucosal damage (SRMD), an erosive process of the gastroduodenum associated with abnormally high physiological demands. Traditionally, treatment options have included sucralfate, antacids and histamine H2 receptor antagonists (H2RAs). The H2RAs are current...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Hong Kong medical journal = Xianggang yi xue za zhi
دوره 13 6 شماره
صفحات -
تاریخ انتشار 2007